Have you been diagnosed with cancer and either your cancer did not respond to treatment or your cancer progressed? If so, you may be able to take part in a research study evaluating the safety of an investigational treatment called LOXO-435 in cancer patients.

The purpose of this study is to test whether the combination treatment of ONC201 and Atezolizumab is safe for the treatment of endometrial cancer.

Have you been diagnosed with colon cancer? If so, you may be able to take part in a research study looking to find out what kind of chemotherapy to recommend to patients based on the presence or absence of circulating tumor DNA (ctDNA) after surgery for colon cancer and if this approach is better or worse than the usual approach for your colon cancer.

This is a study for people diagnosed with Acute Myeloid Leukemia and Myelodysplastic Syndromes who are receiving treatment with hypomethylating agents and Venetoclax. Specifically, we want to learn more about nutrition, eating, and mealtimes for older adults (age 60+) with these conditions and their care partners. Care partners can be a spouse, family member, or friend helping a patient with AML/MDS. We want to understand nutrition, eating, and mealtimes over time throughout the first two cycles of treatment. We also want to learn more about the quality of life for patients and care partners.

The purpose of this study is to learn more about how an investigational drug (tarlatamab) works in people with extensive-stage small cell lung cancer. In this study, we want to learn more about its safety and tolerability (effects good or bad) when used in combination with one of two other drugs (atezolizumab or durvalumab). We also want to learn more about the combination of the study drug with either atezolizumab or durvalumab and carboplatin and etopopside.

To determine optimal content and design features of mHealth apps for smoking cessation that are most preferred by Black and African American adults who smoke or use other tobacco products.

During puberty, adolescents grow and change a lot which may make life seem more stressful and emotional. Male and female adolescents experience the changes associated with puberty differently, possibly because of different responses to changes in hormones, including testosterone and estrogen. We are interested in learning more about the role of these hormones in regulating emotional processing and mood symptoms, and whether a mobile training program can help improve mood during the pubertal transition. Participation is 8 weeks with two monthly follow-up surveys. Compensation provided.

Have you been diagnosed with HER2 positive (HER2+) breast cancer and have recently or plan to undergo surgery? If so, you may be able to take part in a research study looking at the safety of giving two drugs trastuzumab and pertuzumab in combination with hormonal therapy after surgery for your breast cancer.

Are you an elderly patient with locally advanced Head and Neck squamous cell carcinoma who is ineligible for standard treatment involving platinum based therapy (e.g. Carboplatin or Cisplatin)? If so, you may be eligible to participate in a clinical research study involving an investigational drug, called NBTXR3.

My team and I have designed an educational website to be used by men and women who have had a recent heart attack. Our goal is for participants who join the study to use the information provided to learn how to improve their self-care to help prevent another heart attack. In order to know whether our educational program is helpful, we are looking for men and women like yourself to try using and give us feedback about it.