The purpose of this study is to compare the bacteria in women who are taking either methenamine hippurate (Hiprex) or nitrofurantoin (Macrobid, Macrodantin) every day to prevent urinary tract infections (UTIs). We will compare bacteria in the bladder, vagina, and rectum. The information we learn by doing this study may help us better understand how these medications work to prevent UTIs.

In this study, we want to hear from patients with metastatic breast cancer about how their oncologists speak with them about their prognosis. We know these conversations can be challenging, and we want to hear from patients and caregivers about what is helpful or not helpful in those conversations. We also want to hear from patients about a breast cancer-specific tool.

We now know there is a link between sedentary behavior (e.g., sitting) and heart disease. However, we do not yet fully understand if sedentary behavior performed in different settings and situations (e.g., sitting alone watching television vs sitting with friends at a bar) differentially impacts heart disease risk. This is what this study aims to find out.

Want to help improve the treatment of people with chronic blood cancers? We are looking for healthy volunteers to take part in a simple blood-draw study. If you are generally healthy and are not taking blood thinners, you may be able to help improve treatment for patients with chronic blood cancers by donating a tablespoon of blood. This study aims to understand why individuals with chronic blood cancers have a high risk of blood clots as compared to healthy individuals, by comparing (1) the ability of blood to clot in a test tube and (2) changes in white blood cells that make them more likely to stick to blood vessels between healthy individuals and individuals with chronic blood cancers.

The purpose of this study is to assess if a filmed dramatized story intervention (telenovela/soap opera) called Infección de Amor (Love Infection), a culturally tailored and technology delivered intervention for Latinas in the United States (US) can help Latinas prevent HIV infection. Participants will be Latinas ages 18-44 years who report sexual activity with a man in the last 6 months, have internet access from any device, and reside in NC.

The purpose of this study is to explore ways to reduce anxiety in young dental patients. Having dental anxiety in childhood can lead to avoiding dental care in adulthood. This can lead to reduced quality of life and many dental problems, such as cavities, extractions, infections and emergent care.

In this study we want to learn more about the factors that affect quality of life for breast cancer survivors. We also want to learn about the common experiences patients face. What we learn in this study could be used in future research to address overlooked challenges for patients in life after treatment.

The purpose of this research study is to identify changes in the language during the COVID-19 pandemic in population with or without a history of trauma.

Many young athletes who tear their ACL have trouble getting back to sport or suffer a second ACL injury once they do. We aim to improve athletes' ability to get back to sport safely. We want to make the activities athletes perform in rehabilitation more closely match the demands of what they do once they return to their sport. We also aim to develop low-cost ways to measure how the knee is moving during those activities. *This study is a collaboration with the UNC Sports Medicine Institute*

Are you pregnant? Are you high risk? We know it is stressful to be pregnant when you are high-risk. We are trying to learn more about how different aspects of your life - including activity, diet, environment, stress level, and social support affect pregnancy outcomes. Compensation provided.