We are doing this study to learn if exercise impacts the effect of social tasks on energy use and heart function. Since exercise may impact metabolic factors such as energy use as well as the impact of social situations on cardiovascular disease, we want to see how exercise impacts the effect of social situations on energy and metabolism, and whether this may affect your heart health.

People with kidney disease that have the APOL1 risk variant are at a greater risk for developing protein in their urine and chronic kidney disease. This research study is being done to determine if the investigational drug, VX-147 can slow or stop the worsening of kidney function as well as target the underlying cause of kidney disease.

The Lower Extremity Assessment Protocol (LEAP) is a program to prevent reinjury and promote long-term health by characterizing muscle function, evaluating movement performance, and monitoring patient-reported outcomes (e.g., pain). The purpose of this study is to learn more about the outcomes following orthopaedic surgery after a lower limb injury. *This study is a collaboration with the UNC Sports Medicine Institute*

The purpose of this study is to learn more about the tolerability and safety of a daily immunotherapy tablet (SLIT-tablet) for people with peanut allergies. The goal of the SLIT-tablet is to increase tolerance to peanut protein, which could reduce the risk of allergic reactions caused by accidental exposure.

In this study, we want to learn more about health behaviors and access to health information from families with children under six.

Have you or your child been diagnosed with type 1 diabetes during the past 12 months? Are you interested in helping researchers learn more about how to delay or prevent type 1 diabetes or how to treat type 1 diabetes? Join a registry to be notified of future opportunities to participate in type 1 diabetes research!

The purpose of this study is to compare the bacteria in women who are taking either methenamine hippurate (Hiprex) or nitrofurantoin (Macrobid, Macrodantin) every day to prevent urinary tract infections (UTIs). We will compare bacteria in the bladder, vagina, and rectum. The information we learn by doing this study may help us better understand how these medications work to prevent UTIs.

In this study, we want to hear from patients with metastatic breast cancer about how their oncologists speak with them about their prognosis. We know these conversations can be challenging, and we want to hear from patients and caregivers about what is helpful or not helpful in those conversations. We also want to hear from patients about a breast cancer-specific tool.

We now know there is a link between sedentary behavior (e.g., sitting) and heart disease. However, we do not yet fully understand if sedentary behavior performed in different settings and situations (e.g., sitting alone watching television vs sitting with friends at a bar) differentially impacts heart disease risk. This is what this study aims to find out.

Want to help improve the treatment of people with chronic blood cancers? We are looking for healthy volunteers to take part in a simple blood-draw study. If you are generally healthy and are not taking blood thinners, you may be able to help improve treatment for patients with chronic blood cancers by donating a tablespoon of blood. This study aims to understand why individuals with chronic blood cancers have a high risk of blood clots as compared to healthy individuals, by comparing (1) the ability of blood to clot in a test tube and (2) changes in white blood cells that make them more likely to stick to blood vessels between healthy individuals and individuals with chronic blood cancers.