Wood smoke pollution is a common problem across the world, including in the US. This wood smoke comes from people using wood to heat and cook, as well as from wildfires. The purpose of this research study is to screen individuals to see how they respond to wood smoke inhalation by measuring cells in sputum (or phlegm, that you cough up) to see if there is an increase in the number of cells after exposure. The exposure will be to 500ug/m3 of WSP for 2 hours, with intermittent exercise on a bicycle and rest. The wood is burned in a typical wood stove and piped into the chamber. There is a specific gene that we believe impacts the response to wood smoke exposure, we will also look to see if you have this gene or not (about 40% -60% of people do).

Will you be treated for Locally Advanced Head and Neck Squamous Cell Carcinoma? Have you been cancer free for at least two years after previous treatment? If so, you may eligible to participate in a clinical research trial aimed to measure the level of ctDNA in the blood before and after treatment.

Teenagers with ADHD are more vulnerable to negative outcomes than teenagers without ADHD, in part because they engage in more extreme risk-taking. The goal of this study is to understand how brain development during puberty may contribute to risk-taking behaviors in adolescence, and how this differs in youth with and without ADHD. We also want to learn how to predict which children are more vulnerable to extreme levels of risk-taking when they become teenagers. This study will help us to identify children who may be at risk for negative outcomes so potential problems can be addressed early and ultimately prevented.

The study is being done to compare two ways of treating patients with a brain injury. At this time medical providers do not know if one way is better than the other. Both ways of treating patients are used in standard of care. None of the treatments in this study are investigational.

This is a research study to find out if Azithromycin or Roflumilast, medicines used in COPD, works better for people with Chronic Obstructive Pulmonary Disease (COPD).

The goal of this study is to develop new diagnostics and vaccines for viruses transmitted by ticks and mosquitoes, called Arboviruses. These infections circulate in tropical areas of the world including Southeast Asia, the Indian subcontinent, parts of Central and South America, and parts of Africa. These viruses cause a wide spectrum of diseases. Common symptoms of these viruses include fever, rash, joint pain, muscle aches, and headache. Sometimes, people do not even realize that they have been infected. Currently, we are studying Zika and Dengue viruses among others. You do not have to have had a known infection to enroll in this study, the only requirement is travel to an area with these viruses.

The purpose of this study is to investigate the health of former women's soccer players.

This study is to see if levels of ozone that you might be exposed to on a normal day can affect your lung function and cause swelling in your airways. We are also looking at new devices that might one day be used to measure someone's response to air pollution and exercise.

If you've had a kidney biopsy and learned you have a specific kidney condition, you might be eligible to join a three-year study. This study looks at how two medicines, when used together, might help treat your condition.

About 1 out of 5 women who are overweight or report snoring will test positive for sleep apnea during pregnancy. The most commonly prescribed treatment for sleep apnea is a small device called a CPAP. The CPAP just helps you to breathe in a normal pattern during sleep. Sleep apnea is common in pregnancy; it can affect the quality of your sleep and how you feel and function during the day. The goal of this study is to understand if using CPAP in pregnancy can help women have healthier pregnancies.