The purpose of this study is to test whether giving the study drug acalabrutinib is safe and could help control B-cell Non-Hodgkin CNS lymphoma that have not gone away, or have come back, after the first round of treatment.

If you are seen at UNC and have been diagnosed with monoclonal gammopathies or amyloidosis, and the disease is affecting your kidneys, we would like your permission to access your medical record to learn about your treatments and how well they work.

The purpose of this study is to learn more about brain AVMs (BAVMs) and bleeding in HHT. We plan to study risk factors for rupture of BAVMs and also for other bleeding and features of HHT disease, including primarily genetics and imaging characteristics of the BAVMs. We hope that knowledge about risk factors will help improve the care and management of HHT patients.

We are looking for people who have survived a stroke on the left side of the brain and also volunteers who have not had a stroke. We want to learn about typical speech variation and differences that occur due to stroke.

The objectives of this study are to determine: 1) the time course of changes in walking movement and physical activity following anterior cruciate ligament (ACL) injury and up to 12 months after ACL reconstruction (ACLR); 2) the associations between walking movement and physical activity with knee joint health outcomes and self-reported knee function up to 12 months after ACLR. *This study is a collaboration with the UNC Sports Medicine Institute*

This study is a pilot test of a 12-week program. In this study, we will use diet and exercise changes, digital tools, and coaching to help individuals with Type 2 diabetes or prediabetes lose weight.

The purpose of this research study is to poll people with osteoarthritis (OA) and healthcare providers who care for individuals with OA to determine what gaps may exist between patients' nutritional and weight management interests and the nutritional counseling/resources that are shared by providers. Patient resources around the topic of nutrition and OA management will then be developed to address these gaps.

The purpose of this study is to evaluate participation in an 8-week community-based, online program for adults that will help them make small changes to their diet, physical activity, and other behaviors to help promote their health or manage their weight. We are interested in who will participate, how much participants will use the program, how many participants are interested in preventing weight gain or losing weight, and how the program will affect eating, physical activity, and stress. This program is based on previous research on approaches the researchers have studied to help people make small changes to their behavior and is being offered in response to an identified need to offer health promotion resources during the COVID-19 pandemic

Tripping while walking is very common after a stroke. The purpose of this study is to determine when a self-induced trip will occur.

People who suffer ACL injuries are at an increased risk for knee osteoarthritis, which can lead to chronic pain and disability. In this study, we want to learn if adding vibration to rehabilitation following ACL reconstruction surgery can improve how your joints move while walking. We also want to learn if this vibration can improve how your muscles work and your quality of life compared to rehabilitation alone. *This study is a collaboration with the UNC Sports Medicine Institute*