Have you been recently diagnosed with Diffuse Large B Cell Lymphoma? Are you over 75 years of age? If so, you may be able to take part in a research study looking at the safety of giving a new study drug CC-486 (oral azacitidine) in addition to the standard chemotherapy drug combination used to treat this disease.

This study is taking place to create a first-year-of-life, MRI-based predictive test for later autism spectrum disorder (ASD) diagnosis. Subjects will travel to UNC to be assessed using MRI as well as behavioral assessments and observations at 6, 12 and 24 months of age. We will also collect information about the subject's family to gather data on their environment.

To evaluate whether early drug treatment extends overall survival compared with delayed drug treatment with high-risk (chronic lymphocytic leukemia [CLL] newly diagnosed asymptomatic CLL/SLL patients.

A team approach looking at two approved treatments for participants with Post Thrombotic Syndrome

In this study, we want to learn more about mental health stigma and mental health history. We also would like to learn about how these factors affect a person's willingness to participate in therapy.

To find the safest and most tolerable dose of CAR.B7-H3 T cells to administer in patients with relapsed/refractory platinum-resistant epithelial ovarian cancer.

Immune checkpoint inhibitors (ICIs) are a type of cancer treatment that work by over-activating the immune system to find and kill cancer cells. This type of treatment can sometimes lead to side effects that look like autoimmune diseases (diseases where the immune system attacks the body). We want to collects samples and clinical data from cancer patients taking ICI therapy to understand why some patients get side effects and others don't.

The purpose of the SUNBEAM study is to learn more about factors that put babies and toddlers at higher risk for developing food allergies and eczema. This is an observational study, where we will follow pregnant mothers and their babies from birth to 3 years to learn more about how allergies develop. We are doing this research because there are currently no reliable ways to predict which children will develop food allergies.

There are 3 different non-invasive devices that are used to test how stiff your arteries are. We want to learn if these devices give us similar measurements. This will allow us to compare data across different devices, which will assist with future research.

We are researching the genetics of those who have major depressive disorder or bipolar disorder and have received or been evaluated for interventional treatments such as ECT (Electroconvulsive Therapy), TMS (transcranial magnetic stimulation), esketamine, and ketamine. "GenECT" is a research study to find ways to improve treatment for severe depression. We want to answer questions like: "Why do some people get severe depression and other people do not?" "Why do interventional treatments like ECT benefit some people more than others?" The GenECT study is a global effort to understand the genetics of severe depression. Dozens of doctors and scientists from around the world are working together with tens of thousands of patients to find out the answers to these questions. UNC is a lead site in this global effort.