The purpose of this research study is to understand how a physical activity program for family members and friends can help improve their physical activity and possibly improve the symptoms of Hispanics/Latinos with osteoarthritis.

The purpose of this study is to identify and genomically-characterize individuals with genetically unexplained neurodevelopmental disorders, such as epilepsy. The overarching goal is to provide patients with improved information about the underlying genetic basis of their disorder and illuminate novel genetically-defined treatment approaches in the future.

The purpose of this study is to identify barriers and facilitators to the implementation of integrative medical group visits (IMGV) for patients with chronic pain in safety-net healthcare settings. IMGV is one of few integrative pain management programs designed specifically for low-income populations. By understanding what it takes to make these programs successful or not, we aim to test strategies to implement IMGV widely in safety-net settings. The goal is to make integrative pain management more accessible to low-income patients.

The purpose of this study is to conduct interviews to hear people's thoughts and feedback on various aspects of conducting syphilis vaccine research at UNC-Chapel Hill and to ask them to complete a brief online survey after their interviews. The information that participants provide will help the clinical trial researchers to better understand what concerns people might have about syphilis vaccine research and to design clinical trials that are acceptable to potential vaccine research participants.

This study is taking place to create a first-year-of-life, MRI-based predictive test for later autism spectrum disorder (ASD) diagnosis. Subjects will travel to UNC to be assessed using MRI as well as behavioral assessments and observations at 6, 12 and 24 months of age. We will also collect information about the subject's family to gather data on their environment.

To evaluate whether early drug treatment extends overall survival compared with delayed drug treatment with high-risk (chronic lymphocytic leukemia [CLL] newly diagnosed asymptomatic CLL/SLL patients.

In this study, we want to learn more about mental health stigma and mental health history. We also would like to learn about how these factors affect a person's willingness to participate in therapy.

The purpose of the SUNBEAM study is to learn more about factors that put babies and toddlers at higher risk for developing food allergies and eczema. This is an observational study, where we will follow pregnant mothers and their babies from birth to 3 years to learn more about how allergies develop. We are doing this research because there are currently no reliable ways to predict which children will develop food allergies.

There are 3 different non-invasive devices that are used to test how stiff your arteries are. We want to learn if these devices give us similar measurements. This will allow us to compare data across different devices, which will assist with future research.

We are researching the genetics of those who have major depressive disorder or bipolar disorder and have received or been evaluated for interventional treatments such as ECT (Electroconvulsive Therapy), TMS (transcranial magnetic stimulation), esketamine, and ketamine. "GenECT" is a research study to find ways to improve treatment for severe depression. We want to answer questions like: "Why do some people get severe depression and other people do not?" "Why do interventional treatments like ECT benefit some people more than others?" The GenECT study is a global effort to understand the genetics of severe depression. Dozens of doctors and scientists from around the world are working together with tens of thousands of patients to find out the answers to these questions. UNC is a lead site in this global effort.