We will be looking at the effectiveness of casting vs. bracing patients in the treatment of Infantile Idiopathic Scoliosis

Recent updates to the clinical practice guidelines of the American Heart Association (AHA) and US Preventive Services Task Force (USPSTF), now recommend against the use of aspirin for primary prevention in older adults due to the associated bleeding risks​. Moreover, it is estimated that 25-40% of older adults continue routine aspirin consumption without evidence-based clinical indications​. Using the emergency department as a platform to evaluate patients' perspectives on discontinuing aspirin in scenarios where the risks or potential drawbacks surpass the benefits. This assessment takes into account the patient's care objectives, existing functionality, life expectancy, values, and preferences.

In this study, we will shadow, interview, and conduct focus groups with adults to learn about what is working well with supporting Black families in Southeatern NC with meeting their breastfeeding goals and what can be improved.

Children diagnosed with Fragile X syndrome and Down syndrome are at substantially increased risk for developing neuropsychiatric disorders including autism spectrum disorder (ASD) and attention-deficit hyperactivity disorder (ADHD). Despite a known genetic cause for each syndrome, substantial clinical variability exists among children with both syndromes, suggesting an important role for genetic background in shaping child outcomes. We will collect behavioral and genetic data from biological parents to model the relative role of genetic background in explaining behavioral, neurobiological, and clinical variability in young children with Fragile X and Down syndrome who have been followed with brain imaging and behavioral testing since infancy.

In 2015 Nepal adopted a new constitution designed to have the country change its governmental structure to have three levels of government: national, provincial, and municipal. For the first time local governments will have decision-making power for their local communities. The Provincial and Local Government Support Program (PLGSP) is a program designed to build capacity of local governments in Nepal to effectively use their new power and run their communities well. This study will evaluate the PLGSP using a case-control design (observing an and measuring metrics over time to see what changes caused different outcomes), before and after surveys, and a synthetic control model (using statistics to learn what may have happened if the PLGSP never happened). Households in 90 communities will be interviewed before PLGSP starts, and 2 years later. We will use this information to estimate the effectiveness of the PLGSP.

This is a 5-year, longitudinal, observational study of adult and pediatric patients (age 2 and above) undergoing IBD therapy designed to specifically address important clinical questions that remain incompletely answered from registration trials. In addition to the study database, a biospecimen repository will also be included so that translational studies of viral resistance, genomics, and biomarkers of response may be performed. Also, the right to collect retrospective data on these IBD patients will be reserved.

This study is trying to understand whether ziltivekimab can help patients who have recently had a heart attack.

To collect quantitative data to: -Primarily gain a better understanding of patients' attitudes and preferences regarding end-of-life care management if they were to develop a high-risk skin cancer. To be more specific, we hope to gain a better understanding of how patients weigh their risk of developing skin cancer while taking immunosuppressants versus the risk of transplant rejection should they choose to stop or lower their immunosuppressants. -Determine how far these kidney transplant recipients travel to obtain skin-related care -Determine how frequently kidney transplant recipients obtain skin exams -Determine patients' baseline knowledge regarding risk of skin cancer while taking immunosuppressants, which are medicines that lowers immune systems -Determine the quality of life of individuals with skin cancer who are kidney transplant recipients

What is the real-world effectiveness of etrasimod in adult patients ages ≥18 years and <65 years with moderately to severely active UC?

We hypothesize a new mentorship program will lead to improved perception about pursuing a career in orthopedic surgery and increase reported competence and confidence related to orthopedic topics delivered through educational sessions.