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UNC-Chapel Hill Department of Neurology

8 studies match your search
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Parkinson's Disease Motivation Study

Are you someone living with Parkinson's disease? If so, you are aware that in addition to symptoms affecting movement, people with Parkinson's disease also experience non-motor symptoms such as problems with mood and motivation which can be difficult to treat. If you have been living with Parkinson's disease for at least 5 years and take medication for Parkinson's disease, you may be eligible to participate in a research study aimed at treating low motivation with a form of non-invasive brain stimulation called transcranial magnetic stimulation (TMS).

Age & Gender
  • 55 years ~ 80 years
  • Male, Female, Gender Inclusive
Study Interest
  • Aging
  • Brain, Head, Nervous System
  • Movement
  • and 2 more
Not currently enrolling

Genetic Determinants of Neurological and Developmental Disorders

The purpose of this study is to identify and genomically-characterize individuals with genetically unexplained neurodevelopmental disorders, such as epilepsy. The overarching goal is to provide patients with improved information about the underlying genetic basis of their disorder and illuminate novel genetically-defined treatment approaches in the future.

Age & Gender
  • 0 days ~ 99 years
  • Male, Female, Gender Inclusive
Study Interest
  • Developmental
  • Genetics and Genetic Disorders
  • Rare Diseases
Open

DLB Consortium

Do you have probable Dementia with Lewy Bodies (DLB), Mild Cognitive Impairment with "high likelihood" DLB, or Parkinson's Disease Dementia (PDD)? You may be able to participate in an observational study to track your disease progression and promote future research.

Age & Gender
  • 40 years ~ 90 years
  • Male, Female
Study Interest
  • Brain, Head, Nervous System
  • Mental and Emotional Health
By physician referral or invitation only

Observational study working with individuals at risk for, or diagnosed with FTLD (frontotemporal lobar degeneration) syndromes. These are neurodegenerative diseases that affect thinking, memory, behavior, judgement and motor skills.

The purpose of this study is to evaluate both sporadic (not inherited), and familial (inherited), forms of frontotemporal lobar degeneration (FTLD). Patients include both those who have symptoms of FTLD and those who do not (yet have a family history involving FTLD). This is an observational study, meaning that there is no investigational treatment involved. We will be working with patients for up to a 5 year period to learn more about FTLD using a neurological exam, tests of memory, behavior, and judgement, MRI, and biospecimen collection (blood and/or CSF). This study involves genetic testing of the genes so far identified to be associated with FTLD. The overall goal is to help better understand FTLD, to better understand the genetics of FTLD, and to use the information we learn to guide improved patient care and potential drug development.

Age & Gender
  • 18 years ~ 99 years
  • Male, Female
Study Interest
  • Aging
  • Genetics and Genetic Disorders
  • Rare Diseases
Visit Location
100% Remote (online, phone, text)
By physician referral or invitation only

Duke/UNC Alzheimer's Disease Clinical Cohort

The purpose of the study is to establish a Clinical Cohort (group) of research participants to examine normal cognition, mild cognitive impairment and Alzheimer's disease and related disorders (ADRD) as people get older. We will be measuring changes in your memory and the way you process information as you age. As part of the study, you will be asked to participate in yearly evaluations of your memory and health. You will have brain imagining done by Magnetic Resonance Imaging (MRI), a lumbar puncture and blood will be drawn at some visits. Also, as part of this research you must designate a "project partner." This should be someone who is familiar with your health and will be able to provide information about your health and wellbeing as appropriate.

Age & Gender
  • 45 years ~ 80 years
  • Male, Female, Gender Inclusive
Study Interest
  • Aging
  • Brain, Head, Nervous System
Visit Location
100% Remote (online, phone, text)
By physician referral or invitation only

HEALEY ALS Platform Trial

The purpose of the HEALEY ALS Platform Trial is to develop and administer various clinical trials under different regimens with ALS to provide multiple treatment options for patients with ALS.

Age & Gender
  • 18 years ~ 99 years
  • Male, Female, Gender Inclusive
Study Interest
  • Brain, Head, Nervous System
  • Chronic Conditions
Visit Location
100% Remote (online, phone, text)
By physician referral or invitation only

Healey ALS Regimen G

The purpose of this study is to test the safety and effectiveness of DNL343.

Age & Gender
  • 18 years ~ 99 years
  • Male, Female, Gender Inclusive
Study Interest
  • Brain, Head, Nervous System
  • Chronic Conditions
Visit Location
100% Remote (online, phone, text)
By physician referral or invitation only

Healey ALS Regimen F

The purpose of this study is to test the safety and effectiveness of ABBV-CLS-7262 on ALS disease progression.

Age & Gender
  • 18 years ~ 99 years
  • Male, Female, Gender Inclusive
Study Interest
  • Brain, Head, Nervous System
  • Chronic Conditions
Visit Location
100% Remote (online, phone, text)
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