Are you an adult with Hereditary Hemorrhageic Telangiectasia (HHT) ? Information about people living with this rare genetic disease HHT is urgently needed. The purpose of this study is to collect a bank of information about people living with HHT to better understand HHT, the symptoms and complications it causes and how the disease impacts people's lives.

Does your child or teen have a history of wheezing or asthma? Your child may be eligible to participate in a registry that will allow us to understand how wheezing and asthma change over time in kids and teens. Compensation provided for in-person study visits. We will also be enrolling some children without a history of wheezing or asthma to serve as a comparison group.

Are you a parent or guardian of an infant with Angelman Syndrome or Fragile X Syndrome? If so, please consider joining our non-invasive brain imaging study, which will help to advance our understanding of the earliest brain and behavior signs of these conditions. A copy of the MRI scan and a summary of behavioral assessments will be shared with the family. Compensation for participation will be provided, and all travel expenses will be covered.

Individuals with a history of anterior cruciate ligament (ACL) injury and have had an ACL reconstruction (ACLR) are at a greater risk for developing osteoarthritis. The greater risk for developing osteoarthritis is likely caused by too little force or physical activity applied to the knee during weightbearing tasks such as walking. To reduce this decrease in forces during walking following an ACLR, we must first develop effective treatments that can train a person to walk in a way that reduces their risk of developing osteoarthritis. The purpose of this research study is to determine the feasibility and the initial effects of a 6-week training program designed to improve walking mechanics of individuals with an ACL reconstruction.

Do you ever wonder if there is a connection between oral and gut health and food allergies? Well, so do we! We are trying to enroll pediatric participants in our registry study to determine what the link is and use it to possibly help treat patients in the future.

Have you been diagnosed with schizophrenia? Have you ever been prescribed clozapine? If you answered yes to both questions, you may be able to participate in a research study to find out how clozapine affects brain function to improve schizophrenia symptoms. Compensation provided.

Help us learn more about COPD! We want to better understand how your body responds to the nasal flu vaccine and its relation to COPD. We are looking for people with COPD and healthy volunteers for this study. Compensation provided.

Do you have COPD or want to help us understand COPD? If so, you may be able to take part in a research study. We want to learn more about how nose inflammation is related to COPD. We are looking for people with COPD and healthy volunteers for this study. Compensation provided.

The IBIS Network recently received a grant from NIH to study brain and behavior development in infants with Down Syndrome as well as non affected infants. The goal of our new study is to identify the features of Down Syndrome at an earlier age. We will be recruiting infants across all IBIS Network locations 6-months of age and younger. Travel and Compensation provided.

Have you been recently diagnosed with Diffuse Large B Cell Lymphoma? Are you over 75 years of age? If so, you may be able to take part in a research study looking at the safety of giving a new study drug CC-486 (oral azacitidine) in addition to the standard chemotherapy drug combination used to treat this disease.