This is an early phase clinical study for people with advanced stage cancer of one of the following types: non-small cell lung cancer, urothelial cancer, endometrial cancer, triple-negative breast cancer, squamous cell carcinoma of the head and neck or cervical cancer. The investigational drug, GEN1046 (DuoBody®-PD-L1x4-1BB), has been given only to a few humans so far and is not approved for sale. This study will test how well the investigational drug works against these cancers and what side effects may occur with GEN1046.

Have you been diagnosed with HER2 positive (HER2+) breast cancer and have recently or plan to undergo surgery? If so, you may be able to take part in a research study looking at the safety of giving two drugs trastuzumab and pertuzumab in combination with hormonal therapy after surgery for your breast cancer.

Do you have a solid tumor? Would you like to have screening done to see if you are eligible for a treatment study? If so, you may be able to take part in a study that will look at your tumor sample to see if you are eligible for another investigational treatment study.

In this study, we want to learn more about the experiences and activities of high school-aged youth after a neurological event. This study will also help us to understand the perspectives of youth and a parent/caregiver through photos and stories.

The purpose of this study is to collect samples from people with abnormal cell growth or a related condition, including brain and nervous system tumors. This study will help researchers understand the causes of the abnormal cell growth in the brain and nervous system, which may help us develop new treatments.

Do you have Stage 4 lung cancer or lung cancer that has come back? Have you previously been treated with chemotherapy and/or immunotherapy? You may be able to take part in a clinical research study to find out if treatment with two study drugs is more effective compared to usual treatments. No additional labs, testing, or questionnaires are required.

Pancreatic cancer has one of the lowest survival rates for all cancers, but there are some people who achieve long-term survival. We are looking at those patients, with the goal of identifying what are some treatments and experiences that do work. Learning about treatment combinations and unique therapies that have led to success can open doors for where our research should be focused moving forward.

Do you have small cell lung cancer (SCLC) or non-small cell lung cancer (NSCLC)? Has your lung cancer come back or did not get better with the last treatment you were given? If so, you may be able to take part in a gene therapy research study that uses your own modified immune cells as treatment.

Do you have Acute Myeloid Leukemia, Myelodysplastic Syndrome, or Chronic Myelomonocytic Leukemia? Are you looking for other treatment options? We are doing a study to find out whether treatment with the study drug (Bexmarilimab) along with standard treatment can help your cancer.

This is a prospective study that will look for the kinetics of circulating tumor DNA (ctDNA) in patients with hematologic and pediatric cancer before and after undergoing standard of care treatment regimens where radiation therapy is a treatment.