Do you have advanced melanoma that has progressed on treatment? Do you have a tumor longer than 1cm in length? If so, you might be able to take part in a study that compares a study treatment (Vusolimogene Oderparepvec and Nivolumab) with your physician's choice of standard of care treatment. Compensation provided.

Have you been diagnosed with hormone receptor (HR+) and human epidermal growth factor receptor 2 (HER2)-negative recurrent or metastatic breast cancer? If so, you may be eligible for a clinical trial investigating the combination of endocrine therapy with alisertib.

Do you have moderate Parkinson's disease with motor symptoms? Are you over 45 years old? You may be able to participate in a research study to find out if a new treatment involving surgery can help with your symptoms. Compensation provided.

Have you been diagnosed with cancer. If so, you may be able to take part in a research study looking to improve cancer care for patients whose treatment outcomes have led to challenges in their quality of life.

Does hypertonic saline improve mucus clearance in bronchiectasis? The purpose of this research study is to evaluate the effects of 7% hypertonic saline (HS) delivered by nebulizer on clearance of mucus from the lungs in people with bronchiectasis. We will compare mucociliary clearance (MCC: a measurement of the rate at which a person's lungs can clear inhaled particles) at baseline, after a single dose of HS, and after two weeks of treatment with HS twice a day. We will also assess response to HS with other outcomes (spirometry, multiple breath washout [MBW], changes in sputum [coughed up mucus or phlegm], and survey responses). Compensation provided. No blood draws required.

Are you a patient with advanced basal-like pancreatic adenocarcinoma? If so this could the a Trial for you to as this is a Phase I/II trial is to evaluate the safety, efficacy and tolerability of low-dose EGFR inhibitors in combination with bi-weekly gemcitabine/nab-paclitaxel (GnP) in subjects with basal tumors

The purpose of this study is to test a brain stimulation device in Adults with Depression. We aim to make sure the device functions as designed and appropriately stores and transmits data.

The purpose of this research study is to investigate how human interpret some predictive learned by AI systems when detecting deceptive hotel reviews and how AI explanations can shape human understanding. For instance, the AI system learns that words like "floor" and "bathroom" are highly predictive of genuine reviews and words like "husband" and "luxury" are highly predictive of deceptive reviews. While the AI system highlights these words by learning from the data, the association between these words and the outcome are not easy to comprehend for humans. Thus, our goal of this research is to investigate how participants interact with machine-generated explanations that are unintuitive, and how participants make use of our developed visualizations and tools to make sense of these unintuitive features.

Is your child being hospitalized at UNC Youth Behavioral Health for suicidal thoughts or behaviors? If so, you may be eligible to participate in a research study to identify the risk factors associated with recurrence of suicidal thoughts after psychiatric hospitalization. Both you and your child must participate to be eligible for the research study. Compensation provided.

The purpose of this study is to test the safety and effectiveness of the test drug IMGN151-1001 on your cancer.