The purpose of the HEALEY ALS Platform Trial is to develop and administer various clinical trials under different regimens with ALS to provide multiple treatment options for patients with ALS.

To determine if individuals with chronic ankle instability (CAI) improve walking gait characteristics (ie step length and width) following two single session interventions that manipulate visual information available while walking.

To evaluate the safety of GBT021601 and its effect on sickle cell complications

Osteosarcoma is the most common primary bone malignancy of childhood and adolescence. Survival rates for patients with standard risk (localized, resectable primary tumors) and high-risk disease (presence of metastases, unresectable or primary pelvic tumors) are 70% and 20-30%, respectively, and have remained unchanged for several decades despite numerous attempts to augment standard therapies. Multi-targeted receptor tyrosine kinase inhibitors (MTKIs), such as cabozantinib, can target signaling pathways that are known to be altered in osteosarcoma. Several MTKIs including cabozantinib have recently shown clinical evidence of activity in prospective studies for both pediatric and adult patients with advanced osteosarcoma. Furthermore, feasibility of administering MTKIs in combination with cytotoxic chemotherapy has previously been shown in patients with AML, hepatocellular carcinoma, and soft tissue sarcomas. Osteosarcoma is the most common primary bone malignancy of childhood and adolescence. Survival rates for patients with standard risk (localized, resectable primary tumors) and high-risk disease (presence of metastases, unresectable or primary pelvic tumors) are 70% and 20-30%, respectively, and have remained unchanged for several decades

To demonstrate efficacy of Bexsero in prevention of urogenital and/or anorectal gonococcal infection. To estimate efficacy of Bexsero in prevention of overall gonococcal infection and by anatomical site (urogenital, anorectal or pharyngeal). To assess safety of Bexsero.

This registry will collect data about pediatric patients with rare genetic diseases. This data and participating patients will enable current and future research aimed at better understanding, diagnosing, and treating patients affected by a wide range of genetic conditions.

to develop a prototype of the decision aid and assess the preliminary acceptability, appropriateness, and feasibility of using the tool to promote uptake of PrEP consultations among female STI and PrEP clinic clients in North Carolina.

This study seeks to form a better understanding of factors that affect researchers' decisions regarding whether and how to measure and report fidelity of implementation strategies. Findings may provide insight into the significant decline in implementation strategy fidelity measurement/reporting quality over time and elucidate ways to improve fidelity measurement of implementation strategies going forward.

To learn more about a condition called microscopic colitis which can cause chronic diarrhea

Screening tool to collect broader demographic and clinical data. Enhance understanding of site specific and trial specific accrual barriers.