This research study is being done in participants with advanced B-cell malignancies such as some types of lymphomas or leukemias. B-cell malignancies express a protein called the Bruton's tyrosine kinase (BTK), which has been shown to help the tumor cells grow and survive. The investigational drug, AC676, has been designed to recognize the BTK protein, and marks it for destruction. By destroying the BTK protein, the malignancy may be stopped from growing. "Investigational" means the study drug being tested is not approved by the FDA. This is an open-label study, meaning all patients who are eligible to participate will receive study drug. The key purposes of this study are to: ● Test the study drug at different dose levels (dose-escalation) and to determine the highest dose that can be taken without side effects that can't be tolerated (referred to as maximum tolerated dose or MTD). ● Determine what dose of

The purpose of this research study is to compare the effectiveness of two combinations of anticancer study drugs in treating your Chronic Lymphocytic Leukemia (CLL). The first combination is sonrotoclax (also known as BGB-11417) and zanubrutinib, while the second combination is venetoclax and obinutuzumab. The aim is to determine which combination of study drugs is more effective in controlling your specific type of cancer,

Are you a male that has been diagnosed with hormone receptor positive and HER2 negative breast cancer? If so, you may be eligible to a clinical trial comparing different endocrine therapies to treat breast cancer prior to surgery.

The purpose of this study is to observe factors that impact creativity and emotion regulation. Participants will complete a 1-hr session online.

Have you been diagnosed with metastatic breast cancer? If so, you may be able to take part in a research study looking at the efficacy of giving a drug called enzalutamide, alone or combined with mifepristone vs standard chemotherapy.

Young adults show very high levels of anxiety and depression, both compared to older adults and to young adults of previous generations. This study is trying to find out why! Our idea is that the way young adults are thinking about the social, political, and ecological stressors in their lives could be different from other ages. Therefore, we are trying to find out what this group is thinking and feeling about these stressors. This might allow psychologists to better treat young adults for these symptoms in the future!

Have you been diagnosed with metastatic breast cancer? If so, you may be able to take part in a research study looking at the safety and efficacy of giving a new drug called DB-1303 vs standard chemotherapy to patients with metastatic breast cancer.

We are looking for adults (21+) to participate in a one-time, in person eye-tracking appointment to help us understand how people view health messages. An eye tracker is a small camera attached to a laptop that can record where on a screen a person is looking.

This study aims to investigate the effectiveness and safety of retatrutide, a new diabetes medication) at doses of 4 mg, 9 mg, or 12 mg that will be taken as a weekly injection for about 1 year, compared to a placebo. A participant's change in HbA1c level will be primary outcome of interest. We are seeking participants with type 2 diabetes that has affected kidney function and are currently taking long-acting insulin with metformin and/or a SGLT2 inhibitor.

To understand the views and perceptions of Ugandan social work academics who utilize decolonial and indigenous theories and practices, including ubuntu, in their work.