The purpose of this research is to test the safety of NXC-201 (a CAR-T cell targeting the BCMA protein) at different doses in participants with relapsed/refractory AL amyloidosis, and to confirm the best dose for further testing. In addition, the study will evaluate the effectiveness of NXC-201 in treating relapsed/refractory AL amyloidosis
The main purpose of this study is to explore how aging affects not only the local organization of hippocampus but also the corresponding global connectivity. Additionally, the findings of age-dependent alteration on hippocampal subfield networks lay the foundation for the development of an early biomarker of Alzheimer's disease.
The goal of this interview is to gather a clinician's perspective on the feasibility and potential integration of a new Geriatric Functional Assessment System (GFAS) into their clinical practice. This proposed system is a clinic-based wearable device designed to collect visual and motion data from older adults during their primary care visits that will help assess physical function. Its goal is to collect and process data, apply machine learning, and enable clinicians to identify early signs of functional decline.
Are you 21+ and regularly drink alcohol? You may be eligible for a study to help us learn what people think about alcohol. Participants who complete the study can earn up to $275 in virtual gift cards.
Do you have cutaneous sarcoidosis? Would you be interested in hearing more about a clinical study on cutaneous sarcoidosis? If so, you may be able to participate in a research study to find out how effective and safe the study medication Brepocitinib is in patient with cutaneous sarcoidosis.
Do you have high blood pressure even though you are taking 3 or 4 different medications to treat it? You might be able to participate in a study to find out if you also have high cortisol levels.
The purpose of this study is to test the effectiveness and safety of the combination of an investigational vaccine, PDS0101, and the standard of care, compared to the standard of care treatment alone.
The main purpose of the study is to determine whether the experimental study drug, AI-081, is safe and well tolerated, and whether it is effective in treating advanced cancer that cannot be removed by surgery or has spread to a different part of the body (metastasis).
Are you interested in an eye-tracking study? Participate in our study! We are giving $15/hour or 1 SONA credit (plus 0.5 extra travel credit). This study is approximately one hour long. This is a research study and not a clinical treatment study. We are researching where people look while they listen to stories and view pictures about such stories. You are eligible to participate if you are 18 years or older, a native speaker of American English, with vision good enough to see and read a computer screen, and able to attend an in-person visit in the Arnold Lab, Room 371, Davie Hall at UNC. You must not have participated in other Arnold lab studies before. If you wear glasses and use lenses as well, we request that you wear lenses for the ease of participation. Also, we request that you not wear any eye makeup during participation.
The purpose of this study is to determine whether a new investigational combination of drugs, that contains belantamab mafodotin with belantamab, will be as effective, and more tolerable, compared to belantamab mafodotin alone in participants with multiple myeloma that has become active again after at least three prior lines of treatment.