Have you been diagnosed with hormone receptor (HR+) and human epidermal growth factor receptor 2 (HER2)-negative recurrent or metastatic breast cancer? If so, you may be eligible for a clinical trial investigating the combination of endocrine therapy with alisertib.

Have you been diagnosed with cancer. If so, you may be able to take part in a research study looking to improve cancer care for patients whose treatment outcomes have led to challenges in their quality of life.

Does hypertonic saline improve mucus clearance in bronchiectasis? The purpose of this research study is to evaluate the effects of 7% hypertonic saline (HS) delivered by nebulizer on clearance of mucus from the lungs in people with bronchiectasis. We will compare mucociliary clearance (MCC: a measurement of the rate at which a person's lungs can clear inhaled particles) at baseline, after a single dose of HS, and after two weeks of treatment with HS twice a day. We will also assess response to HS with other outcomes (spirometry, multiple breath washout [MBW], changes in sputum [coughed up mucus or phlegm], and survey responses). Compensation provided. No blood draws required.

Are you a patient with advanced basal-like pancreatic adenocarcinoma? If so this could the a Trial for you to as this is a Phase I/II trial is to evaluate the safety, efficacy and tolerability of low-dose EGFR inhibitors in combination with bi-weekly gemcitabine/nab-paclitaxel (GnP) in subjects with basal tumors

Is your child being hospitalized at UNC Youth Behavioral Health for suicidal thoughts or behaviors? If so, you may be eligible to participate in a research study to identify the risk factors associated with recurrence of suicidal thoughts after psychiatric hospitalization. Both you and your child must participate to be eligible for the research study. Compensation provided.

Do you drink alcohol regularly? Do you own an iPhone with Apple iOS 6 or higher? If so, you may be able to take part in a study looking at responses to alcohol and drinking behavior in people who drink alcohol regularly. We want to see how people's bodies react to alcohol in the lab and outside of it. Compensation provided.

Are you 14 to 18 weeks pregnant with one baby? If so, you may be able to take part in a study on how stress and discrimination during pregnancy affect your health. We want to prevent high blood pressure and give better care to pregnant women.

This is a clinical research study opportunity for people with Type 2 Diabetes using long-acting insulin. In this study, we want to learn more about an innovative approach for improving diabetes outcomes using Fractyl Health's Revita System for removing excess tissue from the small intestine. This minimally invasive procedure is believed to improve blood sugar control and overall metabolic health by altering the body's hormonal response to food intake in a similar way to that achieved with bypass surgery. If you are interested in learning more, please contact us!

Have you been diagnosed with relapsed or refractory light chain amyloidosis? If so, you may be able to take part in a research study looking at the safety and tolerability of giving Venetoclax, MLN9708 (ixazomib citrate) and Dexamethasone to patients with relapsed or refractory light chain amyloidosis.

Have you been diagnosed with aggressive B-cell lymphomas and received CAR-T treatment? If so, you may be able to take part in a research study. This study is looking at the efficacy of giving an investigational drug called Epcoritamab in comparison with no treatment. The participants should have received CAR-T treatment but did not have complete remission.