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UNC-Chapel Hill Department of Neurology

41 studies match your search
Open

Parkinson's Disease Motivation Study

Are you someone living with Parkinson's disease? If so, you are aware that in addition to symptoms affecting movement, people with Parkinson's disease also experience non-motor symptoms such as problems with mood and motivation which can be difficult to treat. If you have been living with Parkinson's disease for at least 5 years and take medication for Parkinson's disease, you may be eligible to participate in a research study aimed at treating low motivation with a form of non-invasive brain stimulation called transcranial magnetic stimulation (TMS).

Age & Gender
  • 55 years ~ 80 years
  • Male, Female, Gender Inclusive
Study Interest
  • Aging
  • Brain, Head, Nervous System
  • Movement
  • and 2 more
By physician referral or invitation only

Validation of the Unified Tremor Rating Scale (UTRS)

Examine the validity and reliability of UTRS in the assessment of essential tremor (ET) and Parkinson tremor.

Age & Gender
  • 18 years ~ 89 years
  • Male, Female, Gender Inclusive
Study Interest
  • Chronic Conditions
  • Movement
Open

A randomized open label trial examining the effectiveness of Ofatumumab versus current therapy on relapsing multiple sclerosis.

Are you between 18 and 45 years of age and diagnosed with multiple sclerosis, without MS relapses within the past year? Are you currently prescribed with MS medication? If so, you may be able to participate in a research study examining whether a switch to a high-efficacy medication- Ofatumumab, would work better for you than your current treatment.

Age & Gender
  • 18 years ~ 45 years
  • Male, Female, Gender Inclusive
Study Interest
  • Chronic Conditions
  • Immune System/Infections
Open

IMVT Batoclimab Efficacy and Safety

The purpose of the current Phase 3 study is to confirm the effectiveness and safety of batoclimab in participants with generalized Myasthenia Gravis in 2 different doses of batoclimab compared to placebo.

Age & Gender
  • 18 years ~ 99 years
  • Male, Female, Gender Inclusive
Study Interest
  • Brain, Head, Nervous System
Open

Parkinson's Disease Genetic Registry

Have you or a family member been diagnosed with Parkinson's Disease? Would you be interested in helping researchers learn more about Parkinson's by giving a blood or saliva sample? If so, you may be eligible to participate in a research study that will utilize genetic testing to provide you more information about the possible roles of your genes in your diagnosis.

Age & Gender
  • 18 years ~ 99 years
  • Male, Female, Gender Inclusive
Study Interest
  • Brain, Head, Nervous System
  • Genetics and Genetic Disorders
  • Movement
Open

Phase 2 Study of ALXN2050 in Generalized Myasthenia Gravis

Study is being conducted to ubderstand the effectiveness of ALXN2050 compared with placebo in the treatment of generalized MG (gMG) based on improvement in the Myasthenia Gravis Activities of Daily Living (MG-ADL) total score

Age & Gender
  • 18 years ~ 99 years
  • Male, Female, Gender Inclusive
Study Interest
  • Brain, Head, Nervous System
Open

Non-invasive brain stimulation for Parkinson's non-motor symptoms

Are you interested in advancing treatments in Parkinson's disease? Did you know that the non-motor symptoms of Parkinson's disease are often very disabling and can lead to poor outcomes with the disease? If you have Parkinson's disease, you may be eligible to take part in a research study to learn if we can use non-invasive brain stimulation to treat these symptoms in Parkinson's disease

Age & Gender
  • 50 years ~ 90 years
  • Male, Female, Gender Inclusive
Study Interest
  • Aging
  • Brain, Head, Nervous System
  • Mental and Emotional Health
  • and 4 more
Not currently enrolling

Cartesian_CD08_MG-001

To assess the safety, tolerability and manufacturing feasibility of Descartes-08 in patients with generalized Myasthenia Gravis

Age & Gender
  • 18 years ~ 99 years
  • Male, Female, Gender Inclusive
Study Interest
  • Bones, Joints, Muscles
  • Brain, Head, Nervous System
Not currently enrolling

Genetic Determinants of Neurological and Developmental Disorders

The purpose of this study is to identify and genomically-characterize individuals with genetically unexplained neurodevelopmental disorders, such as epilepsy. The overarching goal is to provide patients with improved information about the underlying genetic basis of their disorder and illuminate novel genetically-defined treatment approaches in the future.

Age & Gender
  • 0 days ~ 99 years
  • Male, Female, Gender Inclusive
Study Interest
  • Developmental
  • Genetics and Genetic Disorders
  • Rare Diseases
Open

Pediatric Relapsing Remitting Multiple Sclerosis Study

If you have a child with MS who is between 10 and 18 years old who has experienced at least one MS episode in the last 12 months, or at least 2 episodes in the last 24 months, your child could qualify for a study testing a drug that is currently used to treat adults with MS.

Age & Gender
  • 10 years ~ 18 years
  • Male, Female, Gender Inclusive
Study Interest
  • Brain, Head, Nervous System
  • Child and Teen Health
  • Immune System/Infections
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