We are seeking participants with type 2 diabetes who use insulin and whose diabetes has affected kidney function and are interested in trying out a new medication that is expected to improve blood sugar control and prevent the weight gain (or induce weight loss) associated with increased insulin use. Compensation for time and travel are provided.

This is a clinical research study opportunity for people with Type 2 Diabetes using long-acting insulin. In this study, we want to learn more about an innovative approach for improving diabetes outcomes using Fractyl Health's Revita System for removing excess tissue from the small intestine. This minimally invasive procedure is believed to improve blood sugar control and overall metabolic health by altering the body's hormonal response to food intake in a similar way to that achieved with bypass surgery. If you are interested in learning more, please contact us!

We're exploring how a special protein supplement called β-hydroxy-methyl-butyrate (HMB for short) could improve mobility in older adults with weakness. It involves just five in-person visits over 12 weeks.

Do you have Alpha-1 Antitrypsin Deficiency? Do you want to participate in research? You may be able to participate in a research project to be contacted for future research studies. Compensation provided.

You and your child may be able to take part in a study designed to help us learn more about what children eat. During several visits that include surveys, taste tests, blood draws and even a brain image, we can learn more about the eating behaviors of children. Compensation provided.

The purpose of this study is to compare diet (record of the foods you eat), gut microbiome (stool sample), and cells (blood sample) in adults with IgA Nephropathy (IgAN) and compare with adults with focal segmental glomerulosclerosis (FSGS) and adults with no history of medical problems. The information we learn by doing this study may help us understand how we might be able to target the microbiome to better understand the disease process and potentially help us develop new therapies in the future.

Do you have Type 2 Diabetes? Is your BMI in the obesity range and you want to lose weight? You may be eligible to participate in a research study to compare the effectiveness of Tirzepatide vs. a combination drug (Cagrilitide and Semaglutide)

Are you interested in losing weight to improve your health? This is an innovative research study that aims to promote weight loss in older adults through either a health coach or a registered dietitian and physical therapist. In those not showing weight loss at 8-weeks, we will try a different strategy to maximize the chance of losing weight. We will provide a gift card incentive for your time.

The study treatment, finerenone, is being developed to help people who have long lasting kidney disease, also known as chronic kidney disease (CKD). It works by blocking a certain hormone called aldosterone that causes injury and inflammation in the heart and kidney which is known to play a role in CKD. In this study, the researchers want to learn if finerenone works the same way in kidney transplant recipients. Some subjects will receive the study drug and some will receive a placebo.

Have you ever wondered what environmental toxins you are exposed to on a daily basis, and how it might affect your health? The STRIVE study is looking for volunteers who would like to provide blood, urine, and/or saliva, as well as home samples such as soil, dust, and/or water. In this study, we want to learn more about the environmental factors that contribute to advanced liver disease and liver cancer. We are looking for healthy volunteers and people with liver cirrhosis who live in either North Carolina or Georgia to take part.