Feel anxious when your body goes into "fight or flight?" You may be eligible to participate in a research study to learn how difficult emotions, such as anxiety and fear, relate to feelings in the body. Compensation provided.

Has your partner ever used a gun to hurt or scare you? Have you ever filed for a protective order in North Carolina? If so, we'd like to talk to you about your experiences. Click the link to find out if you qualify for a research study about domestic violence protective orders and guns. Participation includes a phone interview and compensation is provided.

Ever wonder how the way you walk may affect your knees? Have you ever had an ACL reconstruction? You may be able to take part in a study to learn more about how different types of force applied to your legs can affect your knee while walking on a treadmill.

This study aims to evaluate the effectand safety of empasiprubart compared with intravenous immunoglobulin (IVIg) treatment in adults with multifocal motor neuropathy (MMN). This study will also check how empasiprubart affects the body, how it is absorbed and removed from the body, and how the immune system reacts to empasiprubart.

The goal of this interview is to gather a clinician's perspective on the feasibility and potential integration of a new Geriatric Functional Assessment System (GFAS) into their clinical practice. This proposed system is a clinic-based wearable device designed to collect visual and motion data from older adults during their primary care visits that will help assess physical function. Its goal is to collect and process data, apply machine learning, and enable clinicians to identify early signs of functional decline.

Are you 21+ and regularly drink alcohol? You may be eligible for a study to help us learn what people think about alcohol. Participants who complete the study can earn up to $275 in virtual gift cards.

Have you been diagnosed with advanced cancer that cannot be removed by surgery or has spread to a different part of the body (metastasis)? Has your disease has been getting worse on standard of care cancer treatment? If so, you may be able to take part in a research study looking at whether the experimental study drug, AI-081, is safe and well tolerated, and whether it is effective in treating advanced or metastatic cancer.

Have you been diagnosed hormone receptor (HR) positive, human epidermal growth factor receptor 2 (HER2) negative, locally advanced or metastatic breast cancer, and have not received any systemic anti-cancer treatment for the disease. The study will explore the effects of the study drug PF-07220060 plus letrozole and if it is more effective compared to currently approved drugs (palbociclib, abemaciclib, or ribociclib) in combination with letrozole. This study is different from your regular medical care. The purpose of your regular medical care is to manage or improve your health, but the purpose of research is to gather information to advance science and medicine and does not replace your regular medical care.

Are you planning on having an IUD placed? If you are already planning to get an IUD, this study gives the chance to receive extra pain medication during insertion. Everyone will receive standard pain medication, and 2/3 of volunteers will receive extra. We are looking to see if giving ketorolac pills 1-hour vs 2-hours before an IUD decreases pain levels. We would need 3 hours of in-person clinic time from volunteers. Compensation provided.

This trial seeks to enroll patients diagnosed with HER2-negative (HER2- low or HER2-0)- MBC who are starting treatment with T-DXd. The purpose is to determine if the test used for HER2+ MBC also works for HER2-low MBC. By participating in this trial, you are contributing to information that may improve the care of future patients with HER2-negative (HER2- low or HER2-0)- MBC. This trial does not require additional biopsies. Only tissue left over from a standard-of-care procedure will be used. The study team will access your medical record to review routine imaging test results as well as track your response to your treatment. Your breast cancer care will be managed by your oncologist, and you won't need to interact with the study team for direct care. No extra visits with the study team are required, except possibly for the initial enrollment.