Were you diagnosed with type 1 diabetes in the last few weeks? We are looking for people who are able to come in for a single visit within 2 months of their diagnosis of type 1 diabetes to collect demographic data and a blood sample. We will be collecting blood for the analysis of a specific genotype to see its distribution among people who are diagnosed with T1D.

Are you living with obesity? Will you be willing to lose 25% of your body weight? You may be able to participate in a study to see if an investigational medication works better than placebo for weight loss. Eligible participants may also be able to enroll in an extension phase after the main study is done, where they will be guaranteed to receive the investigational medication.

Are you currently using insulin to treat type 2 diabetes? Are your blood sugar values still not where your provider wants them to be? If you are willing to use an automated insulin delivery system, involving an insulin pump and a continuous glucose monitor, you may be eligible to participate in a research study to find out if the twiist system can improve glycemic control.

Do you have type 2 diabetes with an A1c that is higher than what your doctor would like it to be? Do you have excess body weight that you would like to lose? If so, you may be eligible to participate in a research study to evaluate the effects of a new combination of medications.

The purpose of this study is to determine the efficacy and safety of an investigational oral medication compared with placebo in people with obesity or overweight with and without type 2 diabetes

Do you have type 1 diabetes? Has your doctor told you that your HbA1c is higher than the goal? Do you also have excess body weight? If you are having a hard time controlling your blood sugar with only insulin, you may be able to participate in a research study to see if taking an investigational medication once weekly can help improve your blood sugar control and reduce your body weight.

Do you have high blood pressure even though you are taking 3 or 4 different medications to treat it? You might be able to participate in a study to find out if you also have high cortisol levels.

What factors influence how the brain takes in sugar to use it as energy? If you are between the ages of 18-45 years old and are healthy and of normal weight, you might be eligible to participate in this study to help us understand how the way sugar enters the body affects how sugar enters the brain.

The purpose of this study is to find out whether the addition of HDV to Humalog® will improve diabetes control by reducing high blood sugar after meals and/or reducing the risk of low blood sugar (hypoglycemia) during insulin treatment. The safety and tolerability of Humalog® with or without added HDV will also be evaluated. The study drugs will be administered by subcutaneous (under the skin) injection.

This study aims to investigate the effectiveness and safety of retatrutide, a new diabetes medication) at doses of 4 mg, 9 mg, or 12 mg that will be taken as a weekly injection for about 1 year, compared to a placebo. A participant's change in HbA1c level will be primary outcome of interest. We are seeking participants with type 2 diabetes that has affected kidney function and are currently taking long-acting insulin with metformin and/or a SGLT2 inhibitor.