To learn more about multidrug-resistant bacteria in persons living with HIV.

Healthcare acquired infections (HAIs) contribute substantially to the burden of morbidity and mortality among hospitalized patients in the United States and are a significant economic burden on the healthcare system. Approximately 3-5% of patients in the United States contract a HAI during the course of their treatment, and an estimated $7-14 billion are spent annually on treating these infections. HAIs also contribute to development of antimicrobial resistance (AMR), placing additional burden on the healthcare system and substantially raising the costs of treatment. Novel microbiome engineering technologies that address the HAI problem are currently being developed by researchers. We will conduct a qualitative study to assess the factors influencing the adoption of novel microbiome engineering among hospital nurses in the United States.

We will interview researchers whose work involves the science of gene editing or policy implications of human gene editing. We will also conduct observations at conferences and other public meetings. The interviews and observations will document researchers' perspectives on the scientific prospects for applying human gene editing to the prevention of disease, enhancement concerns that might be generated, and views on the appropriate governance of human genome editing research.

To develop novel PROs for evaluating QoL among patients after IPAA, including those with acute pouchitis and chronic pouch-related conditions.

The goal of this study is to see how well a medication called Cemiplimab works when it's injected directly into a skin cancer, instead of using surgery.

To test the safety of the trial drug, MK-8527 compared to emtricitabine/tenofovir (FTC/TDF) and to see how well MK-8527 works to reduce the chance of getting HIV-1 infection compared to FTC/TDF.

This study aims to understand how the cities of Durham and of Chapel Hill have changed over time. It seeks to engage neighborhood level change and gain insight into placemaking and engagement with planning processes on a local level.

The main purpose of this study is to determine how much MRTX849 can safely be administered to people. This will include looking at what side effects occur and how often they occur.

This study is an access and distribution protocol for unlicensed cryopreserved cord blood units (CBUs) in pediatric and adult patients with hematologic malignancies and other indications. This protocol will allow access to cord blood units that are unlicensed.

Hurricanes and other extreme storms often cause damage in North Carolina. This study collects data from communities and households to understand the short and long term impacts of these events and how individuals, families, and communities respond to and recover from them. The data will help us assess the full costs of extreme events and what families need in their aftermath.