The main purpose of the study is to determine whether the experimental study drug, AI-081, is safe and well tolerated, and whether it is effective in treating advanced cancer that cannot be removed by surgery or has spread to a different part of the body (metastasis).

We are looking for adults ages 18-55 who are interested in using digital tools, a website, and text messages to help them make positive changes in their eating, activity, and weight.

Are you interested in an eye-tracking study? Participate in our study! We are giving $15/hour or 1 SONA credit (plus 0.5 extra travel credit). This study is approximately one hour long. This is a research study and not a clinical treatment study. We are researching where people look while they listen to stories and view pictures about such stories. You are eligible to participate if you are 18 years or older, a native speaker of American English, with vision good enough to see and read a computer screen, and able to attend an in-person visit in the Arnold Lab, Room 371, Davie Hall at UNC. You must not have participated in other Arnold lab studies before. If you wear glasses and use lenses as well, we request that you wear lenses for the ease of participation. Also, we request that you not wear any eye makeup during participation.

Are you a Black undergraduate student involved in performing arts or other extracurricular activities? Do you want to share how these activities impact your academic success, personal growth, and identity? If so, you may be eligible to participate in a research study exploring the connections between extracurricular involvement, cultural influences, and student wellbeing. Your insights can help shape understanding of Black student experiences at predominantly white institutions.

The purpose of this study is to determine whether a new investigational combination of drugs, that contains belantamab mafodotin with belantamab, will be as effective, and more tolerable, compared to belantamab mafodotin alone in participants with multiple myeloma that has become active again after at least three prior lines of treatment.

Are you in perimenopause? Are you interested in lifting weights and taking creatine supplements? Do you want to learn more about your body and brain? If so, you may be able to participate in a research study to understand the impact of resistance training and creatine on muscle quality and cognition in perimenopause!

Are you planning on having an IUD placed? If you are already planning to get an IUD, this study gives the chance to receive extra pain medication during insertion. Everyone will receive standard pain medication, and 2/3 of volunteers will receive extra. We are looking to see if giving ketorolac pills 1-hour vs 2-hours before an IUD decreases pain levels. We would need 3 hours of in-person clinic time from volunteers. Compensation provided.

This trial will follow approximately 200 patients with HER2 negative (HER2- low or HER2-0)- (IHC<2+) MBC who are starting T-DXd. The study will test a newly developed test to measure HER2 protein on tumor cells using an antibody that 'lights up' when attached to HER2. The 'light' is called fluorescence. Cells with HER2 light up when viewed under a microscope with a special light. The fluorescence strength matches with the amount of HER2 protein on the breast cancer cell. We propose to prove this test works in patients with MBC that is HER2 low (IHC<2+) and who are beginning treatment with T-DXd. Each patient in this study will have their tumor tested using this new fluorescence test (Quantitative Immunofluorescence, or QIF). Patients will be followed for response to T-DXd. We will compare the QIF score with IHC score as they relate to patients who benefit from T-DXd.

To determine the anti-proliferative effect of tirzepatide on the endometrium of endometrial cancer (EC) patients .

If you have protein in the urine and African descent, Hispanic or American Indian you might have a gene call APOL1 contributing kidney disease. This study will test if you have change in the gene. If you do have that change you can participate in this study .