Do you have plaque type psoriasis? You may be able to participate in a research study to find out if an investigational medication (zasocitinib) works better than an already FDA approved medication for psoriasis (deucravacitinib).

This study is being done to see if an investigational medication works better than a placebo (dummy medicine) for weight loss.

We are conducting two 3 hour in-person workshops with young adults who consume alcohol to support the development of an intervention which uses social medial to address the link between alcohol use and cancer risk.

The purpose of this study is to collect cells from your esophagus using a special tool called the EndoSign® Cell Collection Device and test them to check for a condition called Barrett's Esophagus and esophageal cancer (EAC).

This research study seeks to improve the treatment of early-stage breast cancer by examining circulating tumor DNA (ctDNA). CtDNA, a biomarker found in the blood, may indicate the presence of residual disease after initial treatment. The study aims to determine if ctDNA analysis can help doctors personalize adjuvant therapies, such as radiation and systemic therapy, leading to more effective treatment plans. A significant focus is placed on including African American/Black patients, a population often underrepresented in genomic research. By analyzing ctDNA in this group, researchers hope to gain valuable insights into the disease's characteristics and improve treatment outcomes, ultimately reducing disparities in breast cancer care. This is a hybrid decentralized study where some if not all assessments may be performed close to your home.

Are you currently using insulin to treat type 2 diabetes? Are your blood sugar values still not where your provider wants them to be? If you are willing to use an automated insulin delivery system, involving an insulin pump and a continuous glucose monitor, you may be eligible to participate in a research study to find out if the twiist system can improve glycemic control.

In this study, we want to see if a new drug called LBS-007 can help treat or cure leukemia. We want to find out if it is safe and if it works well for people with this disease.

Big Discoveries Start Small! Looking for Young Explorers to Join Our Screen Time Study Have a child ages 3-8? Spectra Discovery is a one-week research study exploring how wearable devices might track screen time in young children. Your child will wear fake glasses, a shirt clip, and a belt activity counter while using a study-provided tablet. Parents will complete brief daily surveys and device logs. Orientation can happen at home or at our Chapel Hill office. Parents are compensated, and kids receive a special thank-you gift! Help us better understand screen use in children-click to learn more.

Do you have type 2 diabetes with an A1c that is higher than what your doctor would like it to be? Do you have excess body weight that you would like to lose? If so, you may be eligible to participate in a research study to evaluate the effects of a new combination of medications.

Do you or your child have alopecia areata? Would you be interested in hearing more about a clinical study on alopecia areata? If so, you may be able to participate in a research study to find out how effective and safe the study medication ritlecitinib is in patients with alopecia areata.