The purpose of this study is to collect cells from your esophagus using a special tool called the EndoSign® Cell Collection Device and test them to check for a condition called Barrett's Esophagus and esophageal cancer (EAC).

In this study, we want to see if a new drug called LBS-007 can help treat or cure leukemia. We want to find out if it is safe and if it works well for people with this disease.

This research study seeks to improve the treatment of early-stage breast cancer by examining circulating tumor DNA (ctDNA). CtDNA, a biomarker found in the blood, may indicate the presence of residual disease after initial treatment. The study aims to determine if ctDNA analysis can help doctors personalize adjuvant therapies, such as radiation and systemic therapy, leading to more effective treatment plans. A significant focus is placed on including African American/Black patients, a population often underrepresented in genomic research. By analyzing ctDNA in this group, researchers hope to gain valuable insights into the disease's characteristics and improve treatment outcomes, ultimately reducing disparities in breast cancer care. This is a hybrid decentralized study where some if not all assessments may be performed close to your home.

to evaluate the efficacy and safety of T-DXd in combination with bevacizumab versus bevacizumab monotherapy as first-line maintenance therapy, in participants with human epidermal growth factor 2 (HER2)-expressing (immunohistochemistry [IHC] 3+/2+/1+) advanced high-grade epithelial ovarian cancer.

Big Discoveries Start Small! Looking for Young Explorers to Join Our Screen Time Study Have a child ages 3-8? Spectra Discovery is a one-week research study exploring how wearable devices might track screen time in young children. Your child will wear fake glasses, a shirt clip, and a belt activity counter while using a study-provided tablet. Parents will complete brief daily surveys and device logs. Orientation can happen at home or at our Chapel Hill office. Parents are compensated, and kids receive a special thank-you gift! Help us better understand screen use in children-click to learn more.

Do you have type 2 diabetes with an A1c that is higher than what your doctor would like it to be? Do you have excess body weight that you would like to lose? If so, you may be eligible to participate in a research study to evaluate the effects of a new combination of medications.

Do you or your child have alopecia areata? Would you be interested in hearing more about a clinical study on alopecia areata? If so, you may be able to participate in a research study to find out how effective and safe the study medication ritlecitinib is in patients with alopecia areata.

Preventing walking disability in our rapidly aging population is an enormous public health challenge. Fundamental to their loss of functional mobility is that the muscles needed to power walking experience decline in function with age. Wearable assistive devices can be designed to augment the function of these muscles and may make walking easier. If you are a healthy older adult, you may be able to participate in a training intervention to determine the feasibility of a passive wearable ankle device that strengthens walking dynamics and decreases fall risk.

Do you have chronic limb-threatening ischemia? This might cause you pain, slow-healing wounds, or make it hard to decide about surgeries and treatments for your leg or foot. We want to hear from you. What has getting the care you need been like? Have you ever felt unsure about your treatment options or needed more support? Sharing your story can help us make care better for others with the same condition. It might help doctors to explain things more clearly, find better ways to manage pain, or support people who worry about their independence. We will talk with you two times-now and again in six months-to hear about your experiences. Your story can help make care easier and better for people in the future.

Are you curious about how social media affects child development? You and your child could participate in an exciting research study at UNC Chapel Hill! Compensation provided.