This project aims to test the cognitive mechanisms involved in language production by healthy adults.

We are studying how well a new medicine called Sacituzumab Tirumotecan works by itself and when combined with another medicine called pembrolizumab. We are comparing these treatments to the usual chemotherapy to see which one is better and safer for people with a specific type of breast cancer that has come back or spread and can't be removed by surgery.

We are conducting two 3 hour in-person workshops with young adults who consume alcohol to support the development of an intervention which uses social medial to address the link between alcohol use and cancer risk.

This study is being done to see if an investigational medication works better than a placebo (dummy medicine) for weight loss.

Do you have plaque type psoriasis? You may be able to participate in a research study to find out if an investigational medication (zasocitinib) works better than an already FDA approved medication for psoriasis (deucravacitinib).

Do you have acid reflux, GERD, or Barrett's Esophagus? Are you having standard of care endoscopies performed? You may be able to participate in a research study testing for Barrett's Esophagus and esophageal cancer. Compensation provided.

Have you diagnosed with lymph node positive early breast cancer, have received surgery, and have not received any systemic or radiation treatment prior to surgery? If so, you may be able to take part in this clinical trial which seeks to improve the treatment of early-stage breast cancer by examining ctDNA, a biomarker found in the blood that may indicate the presence of disease. This study aims to determine if ctDNA can help doctors personalize therapies leading to more effective treatment plans.

Have you been diagnosed with Leukemia? Do you have a functioning kidney, liver, and cardiac organ? If so, you may be able to participate in a study on a new drug called LBS-007. We want to find out if it is safe for people with Leukemia. Compensation provided.

Spectra Discovery is a research study looking to see if wearable devices can measure screen time use in children ages 3 to 8. Your child will wear fake glasses and a shirt clip with light sensors to track light from screens. They will also wear an activity counter around their waist to track movement. During the study, your child will use a study-provided Android tablet, which includes an app to track screen use. The study lasts one week and includes: a baseline survey, daily time-use surveys, device logs at the end of each day, and a follow-up survey. To get started, parents will complete an online baseline survey and schedule an in-person orientation, either at home or at our Chapel Hill office. Families will be compensated for their time, and children will receive a thank-you gift. This study helps us learn if these wearable devices can measure screen use in young children.

Do you or your child have alopecia areata? Would you be interested in hearing more about a clinical study on alopecia areata? If so, you may be able to participate in a research study to find out how effective and safe the study medication ritlecitinib is in patients with alopecia areata.