This clinical trial is studying two different investigational treatments for patients with a blood disorder called myelodysplastic syndromes (MDS) who have a specific genetic mutation (IDH1) and have not been treated with certain drugs before. The study will compare the effects of two study drugs, Ivosidenib (IVO) and Azacitidine (AZA), given separately, to see how well they help patients. Researchers will track how many patients experience improvements, how long the treatment effects last, and overall survival.

If you have bronchiectasis and have needed antibiotics for worsening symptoms or flare-ups in the past year, you might be eligible to try a new inhaled medication called Ensifentrine. We want to see if this medication can help reduce symptoms and prevent flare-ups. You will be compensated for your participation.

Do you experience symptoms of depression? If you are a full-time college, graduate or professional student, you may be able to take part in a research study looking at brain activity of therapist and client during a single session intervention targeting depression symptoms. Compensation provided.

We know it is hard to find an exercise program that is designed just for you. We have created a new version of an exercise program called the Physical Activity and Community EmPOWERment (PACE) program, an exercise program that helps people be more active. We are looking for people with intellectual disabilities and their caregivers to participate in a research study testing an exercise program.

We want to learn how personality traits relate to how adolescents and young adults who are shy or whose emotions and moods change quickly make decisions. We hope this research will help us better understand decision-making and mental health during the transition from adolescence to adulthood.

Are you a Black Adult interested in lowering your blood pressure? Interested in changing the way you eat? Do you sit too much at work? If you are interested in changing your lifestyle, want to lose some weight, and have a family member that wants to participate with you, you may be able to participate in a research study. Compensation provided.

Do you identify as Malaysian? Are you a part of a religious organization in Malaysia? Are you interested in the state of gender equality in Malaysia? If so, you will be able to participate in a study on the challenges men in Malaysia face when involved in gender equality work. We will also explore people's opinions on their involvement. Compensation provided.

Do you have incurable, metastatic, or recurrent head and neck squamous cell carcinoma? If so, you may be able to participate in a study to evaluate the addition of the anti-cancer drug, Cetuximab, to standard of care treatment.

Have you been diagnosed with early-stage breast cancer or ductal carcinoma in situ (DCIS) and have undergone breast conserving surgery (lumpectomy). If so this may be the research for you!! You may be able to take part in a research study to evaluate the effects of the tumor bed boost when given at the same time (called a simultaneous integrated boost, SIB) with the WBI, as opposed to after the WBI.

Have you been diagnosed with a blood cancer that can be treated by transplant? If so, you might be eligible to take part in a study that will compare combinations of drugs to see which combination is better at preventing graft-versus-host disease.