This trial will follow approximately 200 patients with HER2-low (IHC<2+) MBC who are starting T-DXd. The study will test a newly developed test to measure HER2 protein on tumor cells using an antibody that 'lights up' when attached to HER2. The 'light' is called fluorescence. Cells with HER2 light up when viewed under a microscope with a special light. The fluorescence strength matches with the amount of HER2 protein on the breast cancer cell. We propose to prove this test works in patients with MBC that is HER2 low (IHC<2+) and who are beginning treatment with T-DXd. Each patient in this study will have their tumor tested using this new fluorescence test (Quantitative Immunofluorescence, or QIF). Patients will be followed for response to T-DXd. We will compare the QIF score with IHC score as they relate to patients who benefit from T-DXd. We propose that QIF will more reliably tell

Are you planning on having an IUD placed? If you are already planning to get an IUD, this study gives the chance to receive extra pain medication during insertion. Everyone will receive standard pain medication, and 2/3 of volunteers will receive extra. We are looking to see if giving ketorolac pills 1-hour vs 2-hours before an IUD decreases pain levels. We would need 3 hours of in-person clinic time from volunteers. Compensation provided.

If you have protein in the urine and African descent, Hispanic or American Indian you might have a gene call APOL1 contributing kidney disease. This study will test if you have change in the gene. If you do have that change you can participate in this study .

Do you have depression and are currently experiencing depression symptoms? We are conducting a treatment trial to see whether non-invasive brain stimulation that matches your brain waves can improve depression symptoms. This is a randomized controlled trial where participants will be randomly assigned to receive active or placebo (fake) stimulation. Compensation is provided.

The purpose of this study is to compare the usual treatment with hormonal therapy medications to treatment with low-dose tamoxifen. This study will help the study doctors find out if this different approach is the same as the usual approach. To decide if it is better, the study doctors will be looking to see if low-dose tamoxifen has the same chance of preventing breast cancer from returning compared to the usual hormonal therapy medications with less side effects

Are you an adult with an intellectual disability (ID/D) age 18 to 30 years? Would you and your adult care partner like to participate in a one-hour zoom interview together to answer questions that can help researchers learn about school and community experiences and technology use that helps people with ID/D transition to adulthood? Digitial gift card compensation provided to both participants.

The goal of this research study is to interview breast cancer survivors who self-identify as Black/African American to obtain feedback and suggestions on refining the FoRtitude 2.0 eHealth intervention.

Do you have metastatic or incurable, recurrent head and neck cancer? If so, you may be able to participate in a research study to find out if a new investigational drug, in combination with pembrolizumab, can help people with advanced head and neck cancer.

In this study, we want to find out if a medicine called Olaparib works as well as the usual treatment for ovarian cancer. We also want to see if this medicine can help stop the cancer from growing or coming back.

The purpose of this research study is to look at a program that includes expert review of your tumor genetic test results. We want to see if this program can help your doctor identify better treatments or suitable clinical trials for your cancer. This is a hybrid decentralized study where some if not all assessments may be performed remotely or close to your home.